| 1 | EC | Avialeasing Aviation Company | ICAO: TWN, Callsign: Twinarrow, Designator EC recalled by IATA. IATA designator changed from AD* | UZ | AVCODES |
| 2 | EC | Heli Inter Riviera | ICAO: HIN, Callsign: Heli Inter, Designator EC* recalled by IATA. Name changed from Heli-Inter SA. | F | AVCODES |
| 3 | EC | Heli-Inter SA | ICAO: HIN, Callsign: Heli Inter, Name changed to Heli Inter Riviera | F | AVCODES |
| 4 | EC | Anglo Airlines Ltd. d/b/a Anglo Cargo Ltd. | ICAO: ANC, Callsign: Anglo, Ceased operations | GB | AVCODES |
| 5 | EC | East African Airways Corporation | Callsign: Eastaf, | EAK | AVCODES |
| 6 | EC | Air Ecosse | | GB | AVCODES |
| 7 | EC | BA European Limited t/a Openskies | ICAO: BOS, IATA Prefix: 284, | GB | AVCODES |
| 8 | EC | Elysair S.A.S. d/b/a L'Avion | ICAO: AVI, IATA Prefix: 284, Merged into Openskies. IATA designator changed from A0. | F | AVCODES |
| 9 | EC | OpenSkies | ICAO: AVI, IATA Prefix: 284, Name changed from Elysair S.A.S. d/b/a L'Avion. Merged into Openskies. IATA designator changed from A0 | F | AVCODES |
| 10 | EC | Openskies | ICAO: BOS, Callsign: Mistral, IATA Prefix: 284, IATA code changed to LV | F | AVCODES |
| 11 | EC | easyJet Europe Airline GmbH | ICAO: EJU, Callsign: Alpine, | A | AVCODES |
| 12 | EC | East African Airways | | EAK | TRAFFIC |
| 13 | ECA | Eurocypria Airlines Ltd. | IATA: UI, Callsign: Eurocypria, IATA Prefix: 475, Liquidated on 29 November 2010 after EU failed to approve merger with Cyprus Airways | CY | AVCODES |
| 14 | ECA | Eagle Commuter Airlines | Callsign: Eagleair, | USA | AVCODES |
| 15 | ECA | OHL Air Charterflug GmbH & Co. KG | Callsign: Dark Knight, Name changed to Excellent Air GmbH. | D | AVCODES |
| 16 | ECA | Excellent Air GmbH | Callsign: Dark Knight, Name changed from OHL Air Charterflug GmbH & Co. KG. | D | AVCODES |
| 17 | ECA | Eurocypria Airlines | IATA: UI | | ICAO1 |
| 18 | ECA | Eisenbahnclub Aschersleben e.V. | Aschersleben | D | privat-bahn.de |
| 19 | ECAA | EXPRESS FUELS INC | | | SCAC4 |
| 20 | ECAD | ENTERPRISE CRUDE OIL LLC | | | SCAC4 |
| 21 | ECAE | EYE CARE ALLIANCE LLC | | | SCAC4 |
| 22 | ECAG | EAST COAST AUTO LOGISTICS LLC | | | SCAC4 |
| 23 | ECAI | EMERALD COAST AIR FREIGHT | | | SCAC3 |
| 24 | ECAJ | ECOTURISTICA | | | SCAC4 |
| 25 | ECAM | ECAM CONTAINER AGENCIES INC | | | SCAC3 |
| 26 | ECAO | ELM CITY AUTO REPAIR LLC | | | SCAC4 |
| 27 | ECAR | ECONOMY CARRIERS LIMITED | | | SCAC3 |
| 28 | ECAR | ECL TRANSPORTATION LTD | | | SCAC4 |
| 29 | ECAU | ENERCON GMBH | | D | BIC |
| 30 | ECAU | ENERCON GMBH | | | SCAC4 |
| 31 | ECAU | ELETRIC Schaltanlagenfertigung GmbH | | DE | VKM |
| 32 | ECB | European Coastal Airlines Ltd. | IATA: H5, Callsign: Coastal Clipper, IATA designator changed to WL | HR | AVCODES |
| 33 | ECB | European Coastal Airlines Ltd. | IATA: WL, Callsign: Coastal Clipper, Ceased operations October 2016. IATA designator changed from H5 | HR | AVCODES |
| 34 | ECB | European Coastal Airlines | | | ICAO1 |
| 35 | ECB | ELECTROCARBON SLATINA SA | | RO | VKM |
| 36 | ECBK | EMERY CUSTOMS BROKERS | | | SCAC3 |
| 37 | ECBK | EMERY CUSTOMS BROKERS | | | SCAC4 |
| 38 | ECBL | EXPRESS CASA BLANCA | | | SCAC4 |
| 39 | ECBN | EXCAVATION CLAUDE BRETON | | | SCAC4 |
| 40 | ECBR | East Cooper and Berkeley R.R. Co. | added 7/1978; 1/1980-7/2000; eliminated 10/2003; 7/2005 | | NAKINA |
| 41 | ECBR | East Cooper and Berkeley R.R. Co. | added 7/78; 1/80-7/2000 | | NRHS |
| 42 | ECBR | EAST COOPER & BERKELEY RAILROAD COMPANY | | | PWRC |
| 43 | ECBR | East Cooper and Berkeley Railroad | | | RSRV |
| 44 | ECBR | EAST COOPER AND BERKELEY RAILROAD C | | | SCAC3 |
| 45 | ECBS | EASTERN CARIBBEAN STEEL IMPORTERS | | | SCAC3 |
| 46 | ECBT | ECONOCARIBE TRUCKING | | | SCAC3 |
| 47 | ECBU | EUROPEAN CONTAINERS NV | | B | BIC |
| 48 | ECBU | EUROPEAN CONTAINERS NV | | | SCAC4 |
| 49 | ECBY | EAST COAST BOAT & YACHT HAULING LLC | | | SCAC4 |
| 50 | ECC | ECA (Europe Continental Airways) d/b/a/ Crossair Europe | IATA: QE, Callsign: Cigigne, Name changed from Europe Continental Airways (ECA) | CH | AVCODES |
| 51 | ECC | Europe Continental Airways (ECA) | IATA: QE, Callsign: Cigigne, Name changed to ECA (Europe Continental Airways) d/b/a/ Crossair Europe. Name changed from European Continental Airways (ECA) | CH | AVCODES |
| 52 | ECC | European Continental Airways (ECA) | IATA: QE, Callsign: Cigigne, Name changed to Europe Continental Airways (ECA) | CH | AVCODES |
| 53 | ECC | Éclair Aviation | Callsign: �clair, | CZ | AVCODES |
| 54 | ECC | Crossair Europe | IATA: QE | | ICAO1 |
| 55 | ECC | EMPIRE COKE COMPANY | | | PWRC |
| 56 | ECC | EAST COAST CARRIERS CONFERENCE | | | SCAC4 |
| 57 | ECCA | ECCA FREIGHT SYSTEMS NEW YORK | | | SCAC3 |
| 58 | ECCA | EXPRESS LOGISTICS INC | | | SCAC4 |
| 59 | ECCD | ENGLISH CONSTRUCTION CO INC | | | SCAC4 |
| 60 | ECCE | EXPRESS CONNECTION CARRIERS INC | | | SCAC4 |
| 61 | ECCG | EXCEL CARTAGE INC | | | SCAC3 |
| 62 | ECCG | ELMAN TRUCKING INC | | | SCAC4 |
| 63 | ECCH | EFFICIENCY COMPANIES INC | | | SCAC4 |
| 64 | ECCI | EXHIBITION CONTRACTORS CO INC | | | SCAC3 |
| 65 | ECCI | ECONOCARIBE CONSOLIDATORS INC | | | SCAC4 |
| 66 | ECCM | EAGLE CAP CAMPERS INC | | | SCAC4 |
| 67 | ECCO | EAST CAROLINA CARTAGE COMPANY INC | | | SCAC3 |
| 68 | ECCO | Ecco Rail | | PL | TRAFFIC |
| 69 | ECCO | ECCO-Cargo-Rail-GmbH | | DE | VKM |
| 70 | ECCOR | Ecco Rail Sp. z o.o. | | PL | VKM |
| 71 | ECCP | ECOLE CORP | | | SCAC3 |
| 72 | ECCR | ECT CORP | | | SCAC3 |
| 73 | ECCR | ECT CORPORATION | | | SCAC4 |
| 74 | ECCS | EAST COAST TRANSPORT INC | | | SCAC3 |
| 75 | ECCS | EARTHLINK CARGO AND CUSTOMS SERVICE | | | SCAC4 |
| 76 | ECCT | ECCARIUS TRUCKING | | | SCAC3 |
| 77 | ECCU | ALOREM | | F | BIC |
| 78 | ECCX | Ethyl Canada Inc. | added 1/1982; 1/1994-7/2000; eliminated 10/2004; 7/2005 (not listed); added 4/2006 | | NAKINA |
| 79 | ECCX | Ethyl Corp. of Canada Ltd. | added 7/1956; 10/1957-1/1980; eliminated 1/1982 | | NAKINA |
| 80 | ECCX | Ethyl Corp. of Canada Ltd. | added 7/56; 10/57-1/80; eliminated 1/82 | | NRHS |
| 81 | ECCX | Ethyl Canada Inc. | added 1/82; 1/94-7/2000 | | NRHS |
| 82 | ECCX | ETHYL CANADA INC. | | | PWRC |
| 83 | ECCX | Ethyl Canada | | | RSRV |
| 84 | ECCX | ETHYL CANADA INC. | | | SCAC4 |
| 85 | ECCY | ELK CREEK COLONY | | | SCAC4 |
| 86 | ECD | Ecotour | Callsign: Ecotour, | MEX | AVCODES |
| 87 | ECD | Ecotour | | | ICAO1 |
| 88 | ECDE | ELITE COURIER & DELIVERY SERVICES | | | SCAC4 |
| 89 | ECDI | E C D INC | | | SCAC3 |
| 90 | ECDL | EXPEDITED COURIER AND DISTRIBUTION | | | SCAC4 |
| 91 | ECDN | EC DISTRIBUTION INC | | | SCAC4 |
| 92 | ECDO | EVERTS COMMERCIAL TRANSPORT INC | | | SCAC3 |
| 93 | ECDP | EPCO CARBON DIOXIDE PRODUCTS INC | | | SCAC4 |
| 94 | ECDS | ECONOMY DELIVERY SERVICE | | | SCAC3 |
| 95 | ECDS | ENCHANTED DESIGNS LTD | | | SCAC4 |
| 96 | ECDU | ECDC ENVIRONMENTAL, LC | | | PWRC |
| 97 | ECDU | ECDC Environmental | | | RSRV |
| 98 | ECDX | Ethyl Corp. | added 4/2006 | | NAKINA |
| 99 | ECDX | Ethyl Petroleum Additives, Inc. | added 1/1985; 1/1994-7/2005; eliminated 1/2006 | | NAKINA |
| 100 | ECDX | Edwin Cooper, Inc. | added 4/1979; 1/1980; eliminated 1/1985 | | NAKINA |
