| 1 | ZA | Access Air, Inc. | ICAO: CYD, Callsign: Cyclone, Ceased operations on 27 February 2001. Operations to start again as Iowair 05/2000 | USA | AVCODES |
| 2 | ZA | ZAS Airlines Of Egypt | ICAO: ZAS, Callsign: ZAS Airlines, | ET | AVCODES |
| 3 | ZA | Genair Ltd. | | GB | AVCODES |
| 4 | ZA | Astair Limited Company | IATA Prefix: 433, Name changed to Interavia Airlines | RUS | AVCODES |
| 5 | ZA | Interavia Airlines | ICAO: SUW, Callsign: Astair, IATA Prefix: 433, Name changed from Astair | RUS | AVCODES |
| 6 | ZA | Skywings Asia Airlines | ICAO: SWM, Callsign: Sky Angkor, IATA Prefix: 969, Name changed to Sky Angkor Airlines w.e.f. 01 December 2014. | K | AVCODES |
| 7 | ZA | Sky Angkor Airlines Co., Ltd. d/b/a Sky Angkor Airlines | ICAO: SWM, Callsign: Sky Angkor, IATA Prefix: 969, Name changed from Skywings Asia Airlines w.e.f. 01 December 2014. | K | AVCODES |
| 8 | ZAAO | ZIMMERMAN TRUCKING | | | SCAC4 |
| 9 | ZABR | Zájazdy Bratislava | | SK | TRAFFIC |
| 10 | ZAC | Zambia Airways | IATA: QZ, Callsign: Zambia, | Z | AVCODES |
| 11 | ZACH | Zakłady Azotowe Chorzów S.A. | | PL | VKM |
| 12 | ZACO | ZARCO 66 INC | | | SCAC4 |
| 13 | ZACT | ZAC-TRANZ | | | SCAC4 |
| 14 | ZACX | Zaclon, Inc. | added 10/1988; 1/1994-7/2005; eliminated 10/2009 | | NAKINA |
| 15 | ZACX | Zaclon, Inc. | added 10/88; 1/94-7/2000 | | NRHS |
| 16 | ZACX | ZACLON, INC. | | | PWRC |
| 17 | ZACX | Zaclon | | | RSRV |
| 18 | ZACX | ZACLON INCORPORATED | | | SCAC4 |
| 19 | ZADE | ZADERAKA TRANSPORT INC | | | SCAC4 |
| 20 | ZADJ | ZADROZNY, J INC | | | SCAC4 |
| 21 | ZAF | Zuckerfabriken Aarberg und Frauenfeld AG | | CH | VKM |
| 22 | ZAFQ | ZAVECO LTD | | | SCAC4 |
| 23 | ZAFU | SAFTAINER | | | SCAC4 |
| 24 | ZAGAN | Miejski Zakład Komunikacyjny Sp. z o.o. w Żaganiu | City: Żagan | PL | TRAFFIC |
| 25 | ZAGI | AGRIPEN INDUST. CAROLINA CORN PROCESSOR | | | PWRC |
| 26 | ZAGR | AGRICO CHEMICAL CO. | | | PWRC |
| 27 | ZAGR | | City: Zagreb | HR | TRAFFIC |
| 28 | ZAGRO | ZAGRO Bahn- und Baumaschi | | DE | VKM |
| 29 | ZAHN | ZAHN, R D TRANSPORTATION COMPANY IN | | | SCAC4 |
| 30 | ZAI | Zaire Aero Service (ZAS) | Callsign: Zasair, | ZRE | AVCODES |
| 31 | ZAI | Zaire Aero Service (ZAS) | IATA: JZ, Callsign: Juliette Zulu, ICAO callsign changed to Zasair | ZAR | AVCODES |
| 32 | ZAI | Zaire Aero Service (ZAS) | IATA: JZ, Callsign: Zasair, ICAO callsign changed from Juliette Zulu | ZAR | AVCODES |
| 33 | ZAI | Zaire Aero Service | | | ICAO1 |
| 34 | ZAJAZD | Przewóz Osób "Zajazd" sp. z o.o. | City: Ruda Slaska | PL | TRAFFIC |
| 35 | ZAK | Zambia Skyways Ltd. | IATA: X7, Callsign: Easair, Designator X7 recalled by IATA, ICAO designator changed from EAZ. Formerly Eastern Air Ltd. / IATA code changed from X7* | Z | AVCODES |
| 36 | ZAK | Zambia Skyways Ltd. | Callsign: Easair, Designator X7 recalled by IATA, ICAO designator changed from EAZ. Formerly Eastern Air Ltd. / IATA code changed from X7* | Z | AVCODES |
| 37 | ZAK | Airlink Zambia | IATA: K8 | | ICAO1 |
| 38 | ZAK | | City: Zakopane | PL | TRAFFIC |
| 39 | ZAKI | Z AND K LEASING INCORPORATED | | | SCAC4 |
| 40 | ZAKR | ZAKRON INDUSTRIES INC | | | SCAC4 |
| 41 | ZALA | Zala Volán | | H | TRAFFIC |
| 42 | ZAMA | U.S. Army Camp Zama | | J | TRAFFIC |
| 43 | ZAMC | Z A M TRANSPORTATION COMPANY INC | | | SCAC4 |
| 44 | ZAMO | ZAMORA TRUCKING | | | SCAC4 |
| 45 | ZAMR | ZAMORA FREIGHT MANAGEMENT LLC | | | SCAC4 |
| 46 | ZAMT | Z AUTOMOTRIZ Y AUTOTRANSPORTE S A D | | | SCAC4 |
| 47 | ZAN | Zantop International Airlines, Inc. | Callsign: Zantop, | USA | AVCODES |
| 48 | ZAN | Zantop International Airlines | | | ICAO1 |
| 49 | ZANT | ZANTINGH SWINE INC | | | SCAC4 |
| 50 | ZANU | ZANZIBAR SHIPPING LINES LIMITED | | EAT | BIC |
| 51 | ZAPN | ZAPIEN TRUCKING | | | SCAC4 |
| 52 | ZAPPA | Zappa Benedetto srl | | I | TRAFFIC |
| 53 | ZAPS | ZAPS TRUCKING INC | | | SCAC4 |
| 54 | ZAPU | GRUPA ZAKLADY AZOTOWE PULAWY SA | | PL | BIC |
| 55 | ZAPU | ZAKLADY AZOTOWA PULAWY SA | | | SCAC4 |
| 56 | ZAPUL | Zakłady Azotowe PUŁAWY S.A. | | PL | VKM |
| 57 | ZAR | Zairean Airlines | IATA: VZ, Callsign: Zairean, Ceased operations. | ZRE | AVCODES |
| 58 | ZAR | Zairean Airlines | | | ICAO1 |
| 59 | ZARL | ZARTRAN LLC | | | SCAC4 |
| 60 | ZARN | ZARNS OIL INC | | | SCAC4 |
| 61 | ZART | ZARO TRANSPORTATION LLC | | | SCAC4 |
| 62 | ZAS | ZAS Airlines Of Egypt | IATA: ZA, Callsign: ZAS Airlines, | ET | AVCODES |
| 63 | ZAS | ZAS Airlines of Egypt | | | ICAO1 |
| 64 | ZAS | ZAS Zweckverband Abfallverw. Südostb. | | DE | VKM |
| 65 | ZAST | Zastava | | YU | TRAFFIC |
| 66 | ZATA | ZAPATA MUNIZ, GUADALUPE | | | SCAC4 |
| 67 | ZATO | ZATOPEK OIL | | | SCAC4 |
| 68 | ZATU | GEODIS ZUST AMBROSETTI SPA | | | SCAC4 |
| 69 | ZATV | ZEEMAN AUTO & TRUCKING SERVICES INC | | | SCAC4 |
| 70 | ZAV | Zhetysu Avia | Callsign: Zhetysu Avia, | KZ | AVCODES |
| 71 | ZAV | Zetavia Limited, Aircompany | IATA: ZK, Callsign: Zetavia, IATA Prefix: 686, | UA | AVCODES |
| 72 | ZAVA | ZAVALZA TRUCKING COMPANY INC | | | SCAC4 |
| 73 | ZAW | Z-Airways & Services Ltd. | Callsign: Zed Air, | BD | AVCODES |
| 74 | ZAW | Zoom Airways | | | ICAO1 |
| 75 | ZAWCO | Zweckverband Abfallwirtschaft Nordwest Oberfranken | | DE | VKM |
| 76 | ZAWI | Zakład Komunikacji Miejskiej w Zawierciu | | PL | TRAFFIC |
| 77 | ZAWK | ZIMMERMANS AUTO WRECKING | | | SCAC4 |
| 78 | ZAZ | | | | TRAFFIC |
| 79 | ZAZA | ZAZUETA TRANSPORT INC | | | SCAC4 |
