| 4301 | DRC | DELAWARE RAILROAD CO. | | | PWRC |
| 4302 | DRCA | DEOL ROAD CARRIER LTD | | | SCAC4 |
| 4303 | DRCE | DIRECT EXPEDITERS INC | | | SCAC4 |
| 4304 | DRCG | DIRECT TRUCKING INC | | | SCAC4 |
| 4305 | DRCH | DREDGE, C. H.,&CO., INC. | | | SCAC1 |
| 4306 | DRCK | DARR TRUCKING | | | SCAC4 |
| 4307 | DRCL | Delaware River Coach Lines | an affiliate of Trans-Bridge Lines | US-NJ | TRAFFIC |
| 4308 | DRCN | D R C ENTERPRISE INC | | | SCAC4 |
| 4309 | DRCO | DIMARCO, P & CO INC | | | SCAC4 |
| 4310 | DRCP | DOUBLE JR INC | | | SCAC4 |
| 4311 | DRCT | DIRECT TRANSPORT INC | | | SCAC4 |
| 4312 | DRCU | DELO LLC | | RUS | BIC |
| 4313 | DRCW | DIRECT RIGHT CARTAGE 2001 INC | | | SCAC4 |
| 4314 | DRCX | Martin Marietta Corp. | added 1/1979; 1/1980; eliminated 7/1986 | | NAKINA |
| 4315 | DRCX | Martin-Marietta Cement, Division of Martin-Marietta Corp. | added 10/1972; 1/1975; eliminated 1/1979 | | NAKINA |
| 4316 | DRCX | Dragon Cement Co., Division of Martin Marietta Corp. | added 7/1969; 4/1970; eliminated 10/1972 | | NAKINA |
| 4317 | DRCX | Dragon Cement Co., Division of Martin Marietta Corp. | added 7/69; 4/70; eliminated 10/72 | | NRHS |
| 4318 | DRCX | Martin-Marietta Cement, Division of Martin-Marietta Corp. | added 10/72; 1/75; eliminated 1/79 | | NRHS |
| 4319 | DRCX | Martin Marietta Corp. | added 1/79; 1/80; eliminated 7/86 | | NRHS |
| 4320 | DRCX | MARTIN MARIETTA CORP. [DENVER RAILWAY CAR COMPANY; DRAGON CEMENT CO.] | | | PWRC |
| 4321 | DRCX | Denver Railway Car Company (Martin Marietta Corporation) | | | RSRV |
| 4322 | DRCY | DAYTON RYDER CUP LLC | | | SCAC4 |
| 4323 | DRCZ | DON RUSS COMPANY | | | PWRC |
| 4324 | DRD | Dardanel Air Havacilik Ve Sanayi Ticaret A.S. | Callsign: Dardanel, | TR | AVCODES |
| 4325 | DRD | Air Madrid Lineas Aereas, S.A. | IATA: NM, Callsign: Alada Air, IATA Prefix: 476, Ceased operations on 15 December 2006. ICAO designator changed from DRI | E | AVCODES |
| 4326 | DRD | Air Madrid | IATA: NM | | ICAO1 |
| 4327 | DRDA | DAFOE, D & R HOLDINGS LTD | | | SCAC4 |
| 4328 | DRDH | DECKS RAILINGS & DESIGN | | | SCAC4 |
| 4329 | DRDI | DRIVER DIRECT 1998 LIMITED | | | SCAC4 |
| 4330 | DRDJ | DOLE ROAD CARRIERS | | | SCAC4 |
| 4331 | DRDK | DESANTIS, D R TRUCKING | | | SCAC4 |
| 4332 | DRDL | DIRECT DELIVERY AND DISTRIBUTION, INC | | | SCAC1 |
| 4333 | DRDL | DIRECT DELIVERY AND DISTRIBUTION IN | | | SCAC4 |
| 4334 | DRDN | DRD INTERNATIONAL INC | | | SCAC4 |
| 4335 | DRDQ | DEFENCE RESEARCH & DEVELOPMENT (AWA | | | SCAC4 |
| 4336 | DRDS | DEBRON DISTRIBUTION SERVICES INC | | | SCAC4 |
| 4337 | DRDT | DESROCHE, D TRUCKING INC | | | SCAC4 |
| 4338 | DRDV | DRW DE DEL RIO CD ACUNA SA DE CV | | | SCAC4 |
| 4339 | DRDW | RAY, DON, DRIVE-A-WAY COMPANY OF CALIFORNIA, INC | | | SCAC3 |
| 4340 | DRDX | The Duredo Co. | added 7/1979; 1/1980; eliminated 4/1986 | | NAKINA |
| 4341 | DRDX | Duredo Co. (John H. Grace Co.) | 1/1950-1/1975; eliminated 7/1979 | | NAKINA |
| 4342 | DRDX | Duredo Co., care of John H. Grace Co. | 4/1947 | | NAKINA |
| 4343 | DRDX | Detroit Reduction Co. | 7/1935-4/1938 | | NAKINA |
| 4344 | DRDX | Detroit Reduction Co. | Apr-38 | | NRHS |
| 4345 | DRDX | Duredo Co. (John H. Grace Co.) | 1/52-1/75; eliminated 7/79 | | NRHS |
| 4346 | DRDX | The Duredo Co. | added 7/79; 1/80; eliminated 4/86 | | NRHS |
| 4347 | DRDX | *DETROIT REDUCTION CO. | | | PWRC |
| 4348 | DRDX | *DUREDO COMPANY (JOHN H. GRACE CO.) | | | PWRC |
| 4349 | DRDX | The Duredo | | | RSRV |
| 4350 | DRDX | THE DUREDO COMPANY | | | SCAC4 |
| 4351 | DRDY | DARBY, PETER | | | SCAC4 |
| 4352 | DRE | Michigan Airways, Inc. d/b/a Drummond Island Air | Callsign: Michigan, | USA | AVCODES |
| 4353 | DRE | Drummond Island Air | | | ICAO1 |
| 4354 | DRE | Deutsche Regionaleisenbahn GmbH | Schönefeld | D | privat-bahn.de |
| 4355 | DRE | BURLINGTON NORTHERN [?] | | | PWRC |
| 4356 | DRE | Deutsche Regional-Eisenbahn | | DE | VKM |
| 4357 | DREAM | Dream Kanko Bus Co. | | J | TRAFFIC |
| 4358 | DREC | DONALDS REFRACTORY REMOVAL SERVICE | | | SCAC4 |
| 4359 | DRED | DAL-RUP EXPRESS INC | | | SCAC4 |
| 4360 | DREE | D & R EXPRESS LLC | | | SCAC4 |
| 4361 | DREG | D & R ENTERPRISES OF GENOA LLC | | | SCAC4 |
| 4362 | DREK | DEERFIELD MOVING & STORAGE | | | SCAC4 |
| 4363 | DRES | DEER RIDGE EQUESTRIAN | | | SCAC4 |
| 4364 | DRES | Dresden, Lilliput Eisenbahn | | D | TRAFFIC |
| 4365 | DRET | DRENNING TRUCKING LLC | | | SCAC4 |
| 4366 | DREX | Protrade Transportation Services, Ltd. | added 4/2007 | | NAKINA |
| 4367 | DREX | Wilmot Transportation & Logistics Ltd. | added 10/2003; 7/2005; eliminated 4/2007 | | NAKINA |
| 4368 | DREX | ProTrade Steel Co., Ltd. | added 10/2001; eliminated 10/2003 | | NAKINA |
| 4369 | DREX | Draper Egg Producers Association, Inc. (North American Car Corp.) | 7/1935 | | NAKINA |
| 4370 | DREX | PROTRADE TRANSPORTATION SERVICES, LTD. (WILMOT TRANSPORTATION & LOGISTICS LTD.; PROTRADE STEEL CORP.) | | | PWRC |
| 4371 | DREX | ProTrade Steel | | | RSRV |
| 4372 | DREX | PROTRADE TRANSPORTATION SERVICES LT | | | SCAC4 |
| 4373 | DREY | DREYER | | | SCAC4 |
| 4374 | DRF | Dream Flyers Training Center | | E | AVCODES |
| 4375 | DRFG | DEANS REFRIGERATED TRUCKING INC | | | SCAC4 |
| 4376 | DRFM | DOUBLE R FARM EQUIPMENT LTD | | | SCAC4 |
| 4377 | DRFS | DRIFTING SUNSHINE ENTERPRISES LLC | | | SCAC4 |
| 4378 | DRFT | DIRECT FREIGHT CORPORATION | | | SCAC4 |
| 4379 | DRFX | Dixie Refining Co. | 7/1923 | | NAKINA |
| 4380 | DRFX | Dixie Refining Co. (Dixie Transportation Co.) | 8/1920 | | NAKINA |
| 4381 | DRFX | DIXIE REFINING CO. (DIXIE TRANSPORTATION CO.) | | | PWRC |
| 4382 | DRG | Italair S.p.A. | IATA: B8, Callsign: Italair, Ceased operations 09/2000 | I | AVCODES |
| 4383 | DRG | DENVER & RIO GRANDE RAILROAD | | | PWRC |
| 4384 | DRG | Denver and Rio Grande Railroad | | | RSRV |
| 4385 | DRG | Deutsche Reichsbahn-Gesellschaft ( - 1945) | | D | TRAFFIC |
| 4386 | DRGC | DRAGE, GARY INC | | | SCAC4 |
| 4387 | DRGE | D R G EXPRESS LLP | | | SCAC4 |
| 4388 | DRGK | DONE RIGHT TRUCKING | | | SCAC4 |
| 4389 | DRGL | DYNAMIC RESOURCES GROUP TECATE LLC | | | SCAC4 |
| 4390 | DRGM | DISTINCTIVE DECOR LTD | | | SCAC4 |
| 4391 | DRGO | DRAGOONS FARM EQUIPMENT INC | | | SCAC4 |
| 4392 | DRGP | DRAGON TRANSPORT LTD | | | SCAC4 |
| 4393 | DRGQ | D R TRANSPORTATION INC | | | SCAC4 |
| 4394 | DRGR | Denver & Rio Grande R.R. Co. | added 7/2008; eliminated 4/2009 | | NAKINA |
| 4395 | DRGR | DENVER & RIO GRANDE RAILROAD CO. | | | PWRC |
| 4396 | DRGR | DENVER & RIO GRANDE RAILROAD COMPAN | | | SCAC4 |
| 4397 | DRGS | DARGUS TRANSPORTATION INC. | | | PWRC |
| 4398 | DRGT | DTI | | | SCAC4 |
| 4399 | DRGW | Union Pacific R.R. Co. | added 7/1997; 7/2000-7/2005 | | NAKINA |
| 4400 | DRGW | Denver & Rio Grande Western R.R. Co. | 1/1975-1/1994; eliminated 7/1997 | | NAKINA |
