| 4401 | DRGW | (D&RGW) Denver & Rio Grande Western R.R. Co. | 4/1970 | | NAKINA |
| 4402 | DRGW | (D&RGW) Denver & Rio Grande Western R.R. Co. | Apr-70 | | NRHS |
| 4403 | DRGW | Denver & Rio Grande Western R.R. Co. | 1/75-1/94; eliminated 7/97 | | NRHS |
| 4404 | DRGW | Union Pacific R.R. Co. | added 7/97; 7/2000 | | NRHS |
| 4405 | DRGW | UP [SP] [DENVER & RIO GRANDE WESTERN] | | | PWRC |
| 4406 | DRGW | Denver and Rio Grande Western Railroad (Union Pacific Railroad) | | | RSRV |
| 4407 | DRGW | Denver & Rio Grande Western Railroad | | USA | TRAFFIC |
| 4408 | DRGX | The Museum of Railway Workers | 7/2005 (not listed) | | NAKINA |
| 4409 | DRGX | Denver & Royal Gorge Ry., LLC | 7/2000 (not listed) | | NAKINA |
| 4410 | DRGX | Denver & Royal Gorge Ry., LLC | Jul-00 | | NRHS |
| 4411 | DRGX | *DENVER & ROYAL GORGE RAILWAY | | | PWRC |
| 4412 | DRGX | +MUSEUM OF RAILWAY WORKERS | | | PWRC |
| 4413 | DRGX | Denver and Royal Gorge Railway | | | RSRV |
| 4414 | DRGX | MUSEUM OF RAILWAY WORKERS, THE | | | SCAC4 |
| 4415 | DRHD | DW FREIGHT INC | | | SCAC4 |
| 4416 | DRHE | DERSCH ENERGIES INCORPORATED | | | SCAC4 |
| 4417 | DRHK | DR HOOK TOWING SERVICES LTD | | | SCAC4 |
| 4418 | DRHL | Dr Richard Herrmann Linienverkehr GmbH | | D | TRAFFIC |
| 4419 | DRHN | DIAMOND RANCH INC | | | SCAC4 |
| 4420 | DRHR | DUARTE, HOMERO A | | | SCAC4 |
| 4421 | DRHY | Durham Transport Inc. | 1/1994 (not listed); added 7/2000; 7/2000 | | NAKINA |
| 4422 | DRHY | Durham Transport Inc. | Jan-94 | | NRHS |
| 4423 | DRHY | Durham Transport | added 7/2000; 7/2000 | | NRHS |
| 4424 | DRHY | DURHAM TRANSPORT INC. | | | PWRC |
| 4425 | DRHY | Durham Transport | | | RSRV |
| 4426 | DRHY | DIAMOND SEAWAYS CORPORATION | | | SCAC4 |
| 4427 | DRI | Air Madrid Lineas Aereas, S.A. | IATA: NM, Callsign: Alada Air, IATA Prefix: 476, ICAO designator changed to DRD | E | AVCODES |
| 4428 | DRI | Davenport, Rock Island & North Western Ry. Co. | 8/1920-1/1994; eliminated 7/1996; 7/2000-7/2005 | | NAKINA |
| 4429 | DRI | Davenport, Rock Island & North Western Ry. Co. | 7/23-1/94; eliminated 7/96; 7/2000 | | NRHS |
| 4430 | DRI | DAVENPORT, ROCK ISLAND & NORTH WESTERN RWY | | | PWRC |
| 4431 | DRI | Davenport, Rock Island and North Western Railway | | | RSRV |
| 4432 | DRI | Davenport, Rock Island & North Western Ry. Co. | | USA | TRAFFIC |
| 4433 | DRIC | DRISCO LLC | | | SCAC4 |
| 4434 | DRID | DRILFORMANCE | | | SCAC4 |
| 4435 | DRIE | DROUIN, N TRANSPORT INC | | | SCAC4 |
| 4436 | DRIF | DRIFTY TRUCKING CO INC | | | SCAC4 |
| 4437 | DRIG | DIGGING AND RIGGING INC | | | SCAC4 |
| 4438 | DRIJ | DRIVE STAR INC | | | SCAC4 |
| 4439 | DRIK | DELMAR COMMODITIES LTD | | | SCAC4 |
| 4440 | DRIM | DART INTERMODAL INC | | | SCAC4 |
| 4441 | DRIN | DA RAN INC | | | SCAC4 |
| 4442 | DRIQ | DERRICO TRUCKING LLC | | | SCAC4 |
| 4443 | DRIR | Denver Rock Island R.R. | added 4/1997; 7/2000; eliminated 10/2001; 7/2005 | | NAKINA |
| 4444 | DRIR | Denver Rock Island R.R. | added 4/97; 7/2000 | | NRHS |
| 4445 | DRIR | DENVER ROCK ISLAND RAILROAD | | | PWRC |
| 4446 | DRIR | Denver Rock Island Railroad | | | RSRV |
| 4447 | DRIR | DENVER ROCK ISLAND RAILROAD | | | SCAC4 |
| 4448 | DRIV | DRIVER TRUCKING INC | | | SCAC4 |
| 4449 | DRIZ | DRACKETT, INC. | | | PWRC |
| 4450 | DRJ | Mid East Air Charters | Callsign: Desert Jet, | SA | AVCODES |
| 4451 | DRJN | DARRAGH, JOHN TRUCKING | | | SCAC4 |
| 4452 | DRJR | DIRICO, R J | | | SCAC4 |
| 4453 | DRJS | DHALIWAL, RAJINDERPAL SINGH | | | SCAC4 |
| 4454 | DRJT | DELGATY, RANDY JOHN | | | SCAC4 |
| 4455 | DRJX | Rail Transportation Technical Services Corp., a Florida Corp. | 7/2005 (not listed) | | NAKINA |
| 4456 | DRJX | RAIL TRANSPORTATION TECHNICAL SERVICES CORP., A FLORIDA CORP. | | | PWRC |
| 4457 | DRJX | RAIL TRANSPORTATION TECHNICAL SERVI | | | SCAC4 |
| 4458 | DRK | Druk Air Corporation Ltd. | IATA: KB, Callsign: Royal Bhutan, IATA Prefix: 787, | BTN | AVCODES |
| 4459 | DRK | Druk Air | IATA: KB | | ICAO1 |
| 4460 | DRK | Deutsche Rotes Kreuz | | D | TRAFFIC |
| 4461 | DRK | Lučební závody Draslovka a.s. Kolín | | CZ | VKM |
| 4462 | DRKC | DRAKE, RICHARD CONSTRUCTION COMPANY | | | SCAC4 |
| 4463 | DRKD | DURKEE DRAYAGE COMPANY | | | SCAC1 |
| 4464 | DRKD | DURKEE DRAYAGE COMPANY | | | SCAC4 |
| 4465 | DRKH | DOYLE, R AND K HARVESTING LTD | | | SCAC4 |
| 4466 | DRKI | DRAKE INTERNATIONAL INC | | | SCAC4 |
| 4467 | DRKL | DRINKA TRUCKING LLC | | | SCAC4 |
| 4468 | DRKP | DRAKE AND SONS TRUCKING | | | SCAC4 |
| 4469 | DRKQ | DRAKE TOWING LTD | | | SCAC4 |
| 4470 | DRKR | DRENTH, K R TRUCKING INC | | | SCAC4 |
| 4471 | DRKS | DORUK SUMMIT TRANSPORT INC | | | SCAC4 |
| 4472 | DRL | Omni Air Transport, LLC | Callsign: Driller, ICAO Designator changed from OAT | USA | AVCODES |
| 4473 | DRLD | DOENZ RANCHES LTD | | | SCAC4 |
| 4474 | DRLF | D R LOGISTICS CORP | | | SCAC4 |
| 4475 | DRLG | DARLING FREIGHT INC | | | PWRC |
| 4476 | DRLI | DIRECT LINES INC | | | SCAC4 |
| 4477 | DRLL | DAVES RECYCLING LLC | | | SCAC4 |
| 4478 | DRLQ | D R LOGISTICS LLC | | | SCAC4 |
| 4479 | DRLR | DRL TRANSPORT ENTERPRISES INC | | | SCAC4 |
| 4480 | DRLT | DRIVE LOGISTICS | | | SCAC4 |
| 4481 | DRLX | Delaware Railcar Leasing, Inc. | added 4/1968; 4/1970-1/1975; eliminated 7/1979 | | NAKINA |
| 4482 | DRLX | Delaware Railcar Leasing, Inc. | added 4/68; 4/70-1/75; eliminated 7/79 | | NRHS |
| 4483 | DRLX | DELAWARE RAILCAR LEASING, INC. | | | PWRC |
| 4484 | DRLX | DELAWARE RAILCAR LEASING, INC. | | | PWRC |
| 4485 | DRM | Aviation South West Limited | Callsign: Dartmoor, | GB | AVCODES |
| 4486 | DRM | Airways Flight Training | | | ICAO1 |
| 4487 | DRMA | DREAME | | | SCAC4 |
| 4488 | DRMD | DURHAM, DUANE | | | SCAC4 |
| 4489 | DRMN | DOGUETS RICE MILLING COMPANY | | | SCAC4 |
| 4490 | DRMQ | DRATON REDI-MIX LTD | | | SCAC4 |
| 4491 | DRMS | DEL RIO MOVING & STORAGE | | | SCAC4 |
| 4492 | DRMV | DOORMAN SERVICE CO INC, THE | | | SCAC4 |
| 4493 | DRMX | Danbury Railway Museum Inc. | 7/2000-7/2005 (not listed) | | NAKINA |
| 4494 | DRMX | Danbury Railway Museum Inc. | Jul-00 | | NRHS |
| 4495 | DRMX | DANBURY RAILWAY MUSEUM, INC. | | | PWRC |
| 4496 | DRMX | DANBURY RAILWAY MUSEUM INC. | | | PWRC |
| 4497 | DRMX | Danbury Railway Museum | | | RSRV |
| 4498 | DRMX | DANBURY RAILWAY MUSEUM INC | | | SCAC4 |
| 4499 | DRMY | DRM TRUCKING LLC | | | SCAC4 |
| 4500 | DRMZ | DRUMMOND | | | PWRC |
