| 4501 | DRN | Central de Discos de Reynosa, S.A. de C.V. | Callsign: Discos Reynosa, | MEX | AVCODES |
| 4502 | DRN | Central De Discos De Reynosa | | | ICAO1 |
| 4503 | DRNC | DRAIN, CARL | | | SCAC4 |
| 4504 | DRND | DARANDY FISHING CO LTD | | | SCAC4 |
| 4505 | DRNK | DRINKS TRUCKING | | | SCAC4 |
| 4506 | DRNO | DURAN OIL COMPANY | | | SCAC4 |
| 4507 | DRNR | DEEP RUN TRANSPORT LLC | | | SCAC4 |
| 4508 | DRNS | DARLEN TRANSPORT (1986) LTD | | | SCAC4 |
| 4509 | DRNT | DURNIN TRUCKING | | | SCAC4 |
| 4510 | DRO | Aeronaves Del Noreste, S.A. de C.V. | Callsign: Aeronoreste, | MEX | AVCODES |
| 4511 | DRO | Adro Servicios Aereos, S.A. de C.V. | Callsign: Adro Servicios, | MEX | AVCODES |
| 4512 | DRO | Aeronaves Del Noreste | | | ICAO1 |
| 4513 | DROE | DROMON ENE | | | SCAC4 |
| 4514 | DROGIN | Drogin Bus Company | | USA | TRAFFIC |
| 4515 | DROH | DROH INC | | | SCAC4 |
| 4516 | DROI | DE LA ROSA OLIVARES, ISMAEL | | | SCAC4 |
| 4517 | DROL | DANIEL, RUSSELL OIL COMPANY INC | | | SCAC4 |
| 4518 | DRON | DRONE, TONY | | | SCAC1 |
| 4519 | DROP | DROPESKI, DAN | | | SCAC4 |
| 4520 | DROQ | DEL-RO TRANSPORTS INC | | | SCAC4 |
| 4521 | DROR | D ROB TRUCKING | | | SCAC4 |
| 4522 | DROU | Drouard | | F | TRAFFIC |
| 4523 | DRP | Deutsche Reichspost | | D | TRAFFIC |
| 4524 | DRPA | DELAWARE RIVER PORT AUTHORITY | | | PWRC |
| 4525 | DRPI | DOUBLE R PERFORMANCE INC | | | SCAC4 |
| 4526 | DRPL | DROUIN, PAUL | | | SCAC4 |
| 4527 | DRPN | DAVIS, RICK PROMOTIONS INC | | | SCAC4 |
| 4528 | DRPT | DESERT REFINED PRODUCTS TRANSPORT I | | | SCAC4 |
| 4529 | DRPX | Dickerson Produce Co. (North Western Refrigerator Line Co.) | 7/1935 | | NAKINA |
| 4530 | DRPZ | DRAKE POWER | | | PWRC |
| 4531 | DRPZ | TRANSPOT INTERNATIONAL POOL INC | | | SCAC4 |
| 4532 | DRQG | DUROCHER, GEORGE & SONS INC | | | SCAC4 |
| 4533 | DRQI | D R TRUCKING INC | | | SCAC4 |
| 4534 | DRR | Airdirect Bedarfsflug GmbH | IATA: X5, Callsign: Aerodirect, Designator X5* recalled by IATA | A | AVCODES |
| 4535 | DRR | Dardanelle & Russellville R.R. Co. | Real: DR | USA | TRAFFIC |
| 4536 | DRRE | DORRIS, ROY E TRANSPORT INC | | | SCAC4 |
| 4537 | DRRF | D R ROOF TRUCKING LLC | | | SCAC4 |
| 4538 | DRRG | DONNELLEY, R R & SONS COMPANY | | | SCAC4 |
| 4539 | DRRH | DELTA RAILROAD CONSTRUCTION INC | | | SCAC4 |
| 4540 | DRRI | Dr. Richard Linien GmbH & Co KG | | A | TRAFFIC |
| 4541 | DRRK | D & R TRUCKING | | | SCAC4 |
| 4542 | DRRN | DORRON ENTERPRISES | | | SCAC4 |
| 4543 | DRRR | D & R TRANSPORT | | | SCAC4 |
| 4544 | DRRS | DARRAS TRANSPORTATION SERVICES INC | | | SCAC4 |
| 4545 | DRRY | DONNELLEY, R R & SONS COMPANY | | | SCAC4 |
| 4546 | DRRZ | DRI RITE | | | PWRC |
| 4547 | DRS | Drenair | Callsign: Drenair, Ceased operations | E | AVCODES |
| 4548 | DRS | Dreamshore Aero | Callsign: Dreamshore, | USA | AVCODES |
| 4549 | DRS | Direct Rail Services | Direct Rail Services (DRS) is a freight operating company created by British Nuclear Fuels Limited. The company started rail operations in 1995 using heavily refurbished Class 20/3 diesel locomotives. Since then it has expanded greatly, and has acquired many more locomotives, most bought second-hand and subsequently refurbished. Ownership of DRS was transferred from BNFL to the Nuclear Decommissioning Authority when the NDA was created on 1 April 2005, under the terms of the Energy Act 2004. DRS remains unique in Britain, remaining a publicly-owned rail freight company. DRS now operates all nuclear-flask trains in the country. | GB | TRAFFIC |
| 4550 | DRS | Direct Rail Services | | UK | VKM |
| 4551 | DRSE | DEARBORN STEEL EXPRESS INC | | | SCAC4 |
| 4552 | DRSF | DROST FARMS | | | SCAC4 |
| 4553 | DRSG | DARAN, SERGIO | | | SCAC4 |
| 4554 | DRSH | DESROCHERS FARMS | | | SCAC4 |
| 4555 | DRSJ | DAMP R SERVICES LTD | | | SCAC4 |
| 4556 | DRSK | DARK STAR TRANSPORT LTD | | | SCAC4 |
| 4557 | DRSL | DUNMORE REPAIR & SALES | | | SCAC4 |
| 4558 | DRSLV | DORSALVE, SL | | ES | VKM |
| 4559 | DRSN | DONALD, RAYMOND & SONS LLC | | | SCAC4 |
| 4560 | DRSR | DAVIS, R S RECYCLING INC | | | SCAC4 |
| 4561 | DRST | D R S TRANSPORT INC | | | SCAC4 |
| 4562 | DRSU | FILTERCARE BV | | NL | BIC |
| 4563 | DRSW | DINGMAN, REGINALD & SONS WOOD PRODU | | | SCAC4 |
| 4564 | DRSX | D.O.T. Rail Services, Inc. | 7/2000-7/2005 (not listed) | | NAKINA |
| 4565 | DRSX | North American Cyanamid Ltd., Welland Works | 4/1947 (not listed) | | NAKINA |
| 4566 | DRSX | D.O.T. Rail Services, Inc. | Jul-00 | | NRHS |
| 4567 | DRSX | D. O. T. RAIL SERVICES, INC. | | | PWRC |
| 4568 | DRSX | *NORTH AMERICAN CYANAMID LTD., WELLAND WORKS | | | PWRC |
| 4569 | DRSX | *D.O.T. RAIL SERVICES, INC. | | | PWRC |
| 4570 | DRSX | D.O.T. Rail Services | | | RSRV |
| 4571 | DRSX | D O T RAIL SERVICES INC | | | SCAC4 |
| 4572 | DRSY | DORSEY TRUCKING INC | | | SCAC4 |
| 4573 | DRT | Aero Charter DARTA | Callsign: DARTA, Founded in 1971. Merged into AeroVision. | F | AVCODES |
| 4574 | DRT | DARTA | Founded in 1971. | F | AVCODES |
| 4575 | DRT | Darta | | | ICAO1 |
| 4576 | DRT | DETROIT RIVER TUNNEL COMPANY | | | PWRC |
| 4577 | DRT | Durham Regional Transit | | CDN | TRAFFIC |
| 4578 | DRT | DRT Danubius Rail Transport Ltd. | | HU | VKM |
| 4579 | DRTC | DMR TRUCK INC | | | SCAC4 |
| 4580 | DRTD | DIRECT DISPATCH TRUCKING LLC | | | SCAC4 |
| 4581 | DRTE | DERSTINE TRUCKING | | | SCAC4 |
| 4582 | DRTJ | D R T LOGISTICS INC | | | SCAC4 |
| 4583 | DRTK | D & R TRUCKING LLC | | | SCAC4 |
| 4584 | DRTN | DEANS, R TRUCKING | | | SCAC4 |
| 4585 | DRTQ | DARQ TRUCKING | | | SCAC4 |
| 4586 | DRTS | D & R TRANSPORT ENTERPRISES | | | SCAC4 |
| 4587 | DRTT | DART TRUCKING COMPANY INC | | | SCAC4 |
| 4588 | DRTU | DART INTERMODAL, INC. | | | PWRC |
| 4589 | DRTU | DART INTERMODAL INC. | | | PWRC |
| 4590 | DRTU | Dart Intermodal | | | RSRV |
| 4591 | DRTW | DRT INTERNATIONAL INC | | | SCAC4 |
| 4592 | DRTY | DIXON, RANDY TRUCKING | | | SCAC4 |
| 4593 | DRTZ | DART INTERMODAL, INC. | | | PWRC |
| 4594 | DRTZ | Dart Intermodal | | | RSRV |
| 4595 | DRTZ | DART INTERMODAL INC | | | SCAC4 |
| 4596 | DRU | Diamonds Of Russia-Sakha | Callsign: Mirny, | RUS | AVCODES |
| 4597 | DRU | Alrosa Company Limited Mirny Air | IATA: 6R, Designator 6R reinstated by IATA | RUS | AVCODES |
| 4598 | DRU | Open Joint Stock Company "ALROSA" (Mirny Air Enterprise) | IATA: 6R, Callsign: Mirny, Designator 6R reinstated by IATA | RUS | AVCODES |
| 4599 | DRU | Alrosa Mirny Air Enterprise | IATA: 6R | | ICAO1 |
| 4600 | DRUK | D & R TRUCKING | | | SCAC4 |
