| 4901 | DSLZ | Intermodal Services Inc. | | | RSRV |
| 4902 | DSLZ | INTERMODAL SERVICES, INC. | | | SCAC4 |
| 4903 | DSM | Aero 2000, S.A. | IATA: 4M, Callsign: Aero Dosmil, Name change to Aero 2000, S.A. dba LAN Argentina | RA | AVCODES |
| 4904 | DSM | Aero 2000, S.A. dba LAN Argentina | IATA: 4M, Callsign: Aero Dosmil, Name changed to LAN Argentina. Name change from Aero 2000, S.A. | RA | AVCODES |
| 4905 | DSM | LAN Argentina S.A. | IATA: 4M, Callsign: Aero Dosmil, IATA Prefix: 469, Name changed from Aero 2000, S.A. d/b/a LAN Argentina w.e.f. 05 May 2016. Name change from Aero 2000, S.A. | RA | AVCODES |
| 4906 | DSM | LAN Argentina S.A. d/b/a LATAM Airlines Argentina | IATA: 4M, Callsign: Aero Dosmil, IATA Prefix: 469, Ceased operations on 17 June 2020. Name changed from Aero 2000, S.A. dba LAN Argentina and previously from Aero 2000, S.A. | RA | AVCODES |
| 4907 | DSM | Aero 2000 | IATA: 4M | | ICAO1 |
| 4908 | DSM | DSM (Staatsmijnen) | | NL | TRAFFIC |
| 4909 | DSMB | DESPIRT MOSAIC & MARBLE CO INC | | | SCAC4 |
| 4910 | DSMC | DESERT MOUNTAIN CORPORATION | | | SCAC4 |
| 4911 | DSMD | DASMOBILE LTD | | | SCAC4 |
| 4912 | DSME | DESPATCH OF SOUTHAMPTON MOVING & ST | | | SCAC4 |
| 4913 | DSMF | DIAMOND S MANAGEMENT LLC | | | SCAC4 |
| 4914 | DSMG | DOWNEY AND SONS MOVING COMPANY | | | SCAC4 |
| 4915 | DSMH | DSM & T CO INC | | | SCAC4 |
| 4916 | DSMP | DSM ENTERPRISES INC | | | SCAC4 |
| 4917 | DSMT | DMTC INC | | | SCAC4 |
| 4918 | DSMU | ZEBRUK LTD | | | SCAC4 |
| 4919 | DSMV | DELANCEY STREET MOVING & TRANSPORTA | | | SCAC4 |
| 4920 | DSMW | DELTA IOS SPECIAL MARITIME ENTERPRI | | | SCAC4 |
| 4921 | DSMY | DES MOINES TRANSPORTATION COMPANY | | | SCAC4 |
| 4922 | DSN | Desna | Callsign: Desna, | UA | AVCODES |
| 4923 | DSN | DESNA | | | ICAO1 |
| 4924 | DSNB | DE SANDRE BROS CO INC | | | SCAC4 |
| 4925 | DSNG | DURANGO & SILVERTON NARROW GAUGE RAILROAD CO. | | | PWRC |
| 4926 | DSNG | DURANGO & SILVERTON NARROW GAUGE RA | | | SCAC4 |
| 4927 | DSNI | DSN EXPRESS INC | | | SCAC4 |
| 4928 | DSNK | D & ST | | | SCAC4 |
| 4929 | DSNL | DIRECT SERVICE NETWORK LTD | | | SCAC4 |
| 4930 | DSNT | DAVISON TRANSPORTATION SERVICES INC | | | SCAC4 |
| 4931 | DSNU | CEA | | F | BIC |
| 4932 | DSNV | DORSEA NAVIGATION LTD | | | SCAC4 |
| 4933 | DSNW | DIVAS SNOWGEAR | | | SCAC4 |
| 4934 | DSO | Dassault Falcon Service | Callsign: Dassault, ICAO designator changed from EFS | F | AVCODES |
| 4935 | DSO | Dassault Falcon Service | | | ICAO1 |
| 4936 | DSO | Donora Southern R.R. (Co.) | 8/1920-4/1961 | | NAKINA |
| 4937 | DSO | Donora Southern R.R. Co. | 23-Jul | | NRHS |
| 4938 | DSO | Donora Southern R.R. | 4/38-4/61 | | NRHS |
| 4939 | DSO | DONORA SOUTHERN RR | | | PWRC |
| 4940 | DSOF | DEEP SOUTH FREIGHT | | | SCAC4 |
| 4941 | DSOL | DAKOTA SOUTHERN LLC | | | SCAC4 |
| 4942 | DSOQ | D & S OILFIELD TRANSPORTATION INC | | | SCAC4 |
| 4943 | DSOS | DELOATCH & SONS | | | SCAC4 |
| 4944 | DSOU | Durham and Southern Ry. Co. | Real: DS | USA | TRAFFIC |
| 4945 | DSOV | DESTINATION OVERIDE INC | | | SCAC4 |
| 4946 | DSP | Suraviation S.L. | Callsign: Suraviation, | E | AVCODES |
| 4947 | DSP&P | DENVER SOUTH PARK & PACIFIC | | | PWRC |
| 4948 | DSPB | DANIELS SHARPSMART CANADA LTD | | | SCAC4 |
| 4949 | DSPC | DISPATCH AMERICA | | | SCAC4 |
| 4950 | DSPD | DESPERADO TRUCKING | | | SCAC4 |
| 4951 | DSPK | DESPERADO TRUCKING INC | | | SCAC4 |
| 4952 | DSPN | D & S TRANSPORT CORP | | | SCAC4 |
| 4953 | DSPS | DESIGN PLUS | | | SCAC4 |
| 4954 | DSPT | DISPATCH TRANSPORTATION INC | | | SCAC4 |
| 4955 | DSPV | DALMARE SPA | | | SCAC4 |
| 4956 | DSPY | DISPLAY TRANSPORTATION | | | SCAC4 |
| 4957 | DSQ | Dasab Airlines | Callsign: Dasab Air, | WAN | AVCODES |
| 4958 | DSQ | Dasab Airlines | | | ICAO1 |
| 4959 | DSQL | D S T LLC | | | SCAC4 |
| 4960 | DSQT | D S | | | SCAC4 |
| 4961 | DSR | Dairo Air Services Ltd. | Callsign: Dairair, Designator SE* recalled by IATA | EAU | AVCODES |
| 4962 | DSR | Dairo Air Services Ltd. | IATA: SE, Callsign: Dairair, Designator SE* recalled by IATA | EAU | AVCODES |
| 4963 | DSR | Dairo air Service Ltd. | IATA: WD, Callsign: Dasair, IATA Prefix: 761, Name changed from DAS Air Limited. IATA code changed from SE* | EAK | AVCODES |
| 4964 | DSR | DAS Air Cargo | IATA: WD | | ICAO1 |
| 4965 | DSR | Department of Street Railways | Real: DSR, City: Detroit | USA | TRAFFIC |
| 4966 | DSRC | Dakota Southern Ry. Co. | added 4/1986; 1/1994-7/2005 | | NAKINA |
| 4967 | DSRC | Dakota Southern Ry. Co. | added 4/86; 1/94-7/2000 | | NRHS |
| 4968 | DSRC | DAKOTA SOUTHERN RAILWAY CO | | | PWRC |
| 4969 | DSRC | Dakota Southern Railway | | | RSRV |
| 4970 | DSRC | Dakota Southern Railway Company | | USA | TRAFFIC |
| 4971 | DSRD | DESERT DELIVERY | | | SCAC4 |
| 4972 | DSRE | DIRECT SUPPORT RESOURCES INC | | | SCAC4 |
| 4973 | DSRG | D S R LOGISTICS | | | SCAC4 |
| 4974 | DSRK | D & S TRUCKING | | | SCAC4 |
| 4975 | DSRL | DANESI USA INC | | | SCAC4 |
| 4976 | DSRP | DESERT STAR TRANSPORTATION LLC | | | SCAC4 |
| 4977 | DSRP | DB Schenker Rail Polska | Real: DBSRP | PL | TRAFFIC |
| 4978 | DSRR | Delta Southern R.R. Co. | 1/1994-7/2005 | | NAKINA |
| 4979 | DSRR | Delta Southern R.R. Co. | 1/94-7/2000 | | NRHS |
| 4980 | DSRR | *DONORA SOUTHERN RAILROAD | | | PWRC |
| 4981 | DSRR | +DELTA SOUTHERN RAILROAD COMPANY | | | PWRC |
| 4982 | DSRR | Delta Southern Railroad | | | RSRV |
| 4983 | DSRR | DELTA SOUTHERN RAILROAD COMPANY | | | SCAC4 |
| 4984 | DSRR | DB Schenker Rail Romania SRL | Real: DBSR | RO | TRAFFIC |
| 4985 | DSRS | DSR/SENATOR JOINT SERVICE | | | SCAC1 |
| 4986 | DSRS | DSR/SENATOR JOINT SERVICE | | | SCAC4 |
| 4987 | DSRT | DESERT MOVING & STORAGE CO INC | | | SCAC4 |
| 4988 | DSRU | DISA RED DE SERVICIOS PETROLIFEROS, S.A. | | E | BIC |
| 4989 | DSRU | VEBDEUT FRACHT SEEDEREIL | | | SCAC3 |
| 4990 | DSRU | VEBDEUT FRACHT SEEDEREIL | | | SCAC4 |
| 4991 | DSRX | DOWNEAST RAIL HERITAGE PRESERVATION TRUST, INC. | | | PWRC |
| 4992 | DSRX | Downeast Scenic Railroad | | | RSRV |
| 4993 | DSRX | DOWNEAST RAIL HERITAGE PRESERVATION | | | SCAC4 |
| 4994 | DSRZ | DAKOTA SOUTHERN RAILWAY CO | | | PWRC |
| 4995 | DSS&A | Duluth, South Shore & Atlantic Ry. | 7/1935-4/1938 | | NAKINA |
| 4996 | DSS&A | Duluth, South Shore & Atlantic Ry. | Apr-38 | | NRHS |
| 4997 | DSS&A | DULUTH, SOUTH SHORE & ATLANTIC RAILWAY | | | PWRC |
| 4998 | DSSA | DULUTH, SOUTH SHORE & ATLANTIC RAILWAY | | | PWRC |
| 4999 | DSSA | Duluth, South Shore & Atlantic Railway (Canadian Pacific Railway) | | | RSRV |
| 5000 | DSSA | Duluth, South Shore & Atlantic Railway | | USA | TRAFFIC |
