| 4501 | EPTC | East Portland Traction Company (Oregon Pacific Railroad) | | | RSRV |
| 4502 | EPTC | EAST PORTLAND TRACTION CO | | | SCAC3 |
| 4503 | EPTD | EXP TRANSPORT INC | | | SCAC4 |
| 4504 | EPTE | EL PASO TEXAS EXPRESS INC | | | SCAC3 |
| 4505 | EPTF | EAGLE POINT FARM | | | SCAC4 |
| 4506 | EPTG | E & P TRUCKING II | | | SCAC4 |
| 4507 | EPTH | EXPRESS TANY | | | SCAC4 |
| 4508 | EPTI | EPIC TRANSPORTATION INC | | | SCAC3 |
| 4509 | EPTK | EP TRUCKING COMPANY INC | | | SCAC3 |
| 4510 | EPTK | EL PINO TRUCKING INC | | | SCAC4 |
| 4511 | EPTM | EDWARDS PETROLEUM TRANSPORT LLC | | | SCAC4 |
| 4512 | EPTN | EXPOL TRUCKING INC | | | SCAC4 |
| 4513 | EPTP | ENTERPRISE TRANSPORTATION | | | SCAC3 |
| 4514 | EPTR | EXPRESS TRANSIT INC | | | SCAC4 |
| 4515 | EPTS | EXPRESS TRANSPORTATION SERVICES INC | | | SCAC3 |
| 4516 | EPTT | EIPERS, TERRY TRUCKING | | | SCAC3 |
| 4517 | EPTV | EAGLE PARLOR TOURS OF VA INC | | | SCAC3 |
| 4518 | EPTV | EP-TEAM INC | | | SCAC4 |
| 4519 | EPTW | EFE PROJECT TRANSPORTATION & LOGIST | | | SCAC4 |
| 4520 | EPTX | ELK POINT TRANSPORTATION CO., LLC | | | PWRC |
| 4521 | EPTX | ELK POINT TRANSPORTATION CO LLC | | | SCAC4 |
| 4522 | EPTY | ERMAR SEA TRANSPORTATION CO INC | | | SCAC3 |
| 4523 | EPU | Aero Elite Acapulco, S.A. de C.V. | Callsign: Elitacapulco, | MEX | AVCODES |
| 4524 | EPUP | EL PASO UNION PASSENGER TERMINAL | | | PWRC |
| 4525 | EPUS | E PLUS TRANSPORTATION | | | SCAC3 |
| 4526 | EPUU | EPU GLOBAL LOGISTICS CO., LIMITED | | PRC | BIC |
| 4527 | EPVC | EXPLOSIVE CONTRACT CARRIERS INC | | | SCAC4 |
| 4528 | EPWC | EXPRESSWAY COURIER INC | | | SCAC3 |
| 4529 | EPX | El Pino, S.A. | 1/1950-1/1975; eliminated 4/1976 | | NAKINA |
| 4530 | EPX | Evansville Packing Co. | 7/1923 | | NAKINA |
| 4531 | EPX | El Pino, S.A. | 1/52-1/75; eliminated 4/76 | | NRHS |
| 4532 | EPX | *EVANSVILLE PACKING CO. | | | PWRC |
| 4533 | EPX | *EL PINO. S.A. | | | PWRC |
| 4534 | EPXA | EXPEDITED TRANSPORT AMALGAMATORS | | | SCAC4 |
| 4535 | EPXC | EXPRESS LINE TRANSPORTATION LLC | | | SCAC4 |
| 4536 | EPXE | EXPERT EXPRESS INC | | | SCAC4 |
| 4537 | EPXN | EP TRANSPORT | | | SCAC4 |
| 4538 | EPXO | EXPRESS TRANSPORTATION | | | SCAC4 |
| 4539 | EPXP | EMPIRE EXPRESS INC | | | SCAC3 |
| 4540 | EPXP | EMPIRE EXPRESS INC | | | SCAC4 |
| 4541 | EPXR | EMPIRE TRANSPORT LLC | | | SCAC4 |
| 4542 | EPXS | EPES EXPRESS SERVICES INC | | | SCAC4 |
| 4543 | EPXT | EXPLORER TRUCKING INC | | | SCAC4 |
| 4544 | EPXX | EL PINO S A | | | SCAC3 |
| 4545 | EPYN | EMPYREA | | | SCAC4 |
| 4546 | EPZA | ELMINI LABOR INC. | | | SCAC3 |
| 4547 | EPZB | ELMINI LAD INC. | | | SCAC3 |
| 4548 | EPZC | ELMINI LAGOON INC. | | | SCAC3 |
| 4549 | EPZD | ELMINI LAMA INC. | | | SCAC3 |
| 4550 | EPZE | ELMINI LANE INC | | | SCAC3 |
| 4551 | EPZG | ELMINI LAP INC. | | | SCAC3 |
| 4552 | EPZH | ELMINI LASS INC. | | | SCAC3 |
| 4553 | EPZI | ELMINI LATRIA INC. | | | SCAC3 |
| 4554 | EPZJ | ELMINI LAUD INC. | | | SCAC3 |
| 4555 | EPZK | ELMINI LAUREL INC. | | | SCAC3 |
| 4556 | EPZL | ELMINI LAW, INC. | | | SCAC3 |
| 4557 | EPZM | ELMINI LEAD, INC. | | | SCAC3 |
| 4558 | EPZN | ELMINI LEAGUE, INC. | | | SCAC3 |
| 4559 | EPZN | ESPINOZA, R TRANSPORT | | | SCAC4 |
| 4560 | EPZO | ELMINI LEE, INC. | | | SCAC3 |
| 4561 | EPZP | ELMINI LEGEND, INC. | | | SCAC3 |
| 4562 | EPZP | ESPINOZAS PRODUCE | | | SCAC4 |
| 4563 | EPZQ | ELMINI LIBRA, INC. | | | SCAC3 |
| 4564 | EPZR | ELMINI LID, INC. | | | SCAC3 |
| 4565 | EPZS | ELMINI LIGHT, INC. | | | SCAC3 |
| 4566 | EPZT | ELMINI LILY, INC. | | | SCAC3 |
| 4567 | EPZT | EMPRIZE TRANSPORT INC | | | SCAC4 |
| 4568 | EPZV | ELMINI LINER, INC. | | | SCAC3 |
| 4569 | EPZW | ELMINI LINK, INC. | | | SCAC3 |
| 4570 | EPZY | ELMINI LIONESS, INC. | | | SCAC3 |
| 4571 | EQ | TAME Linea Aerea del Ecuador | ICAO: TAE, Callsign: Tame, IATA Prefix: 269, Ceased operations on 19 May 2020. | EC | AVCODES |
| 4572 | EQ | Excalibur Airways Ltd. | ICAO: EXC, Callsign: Excalibur, Ceased operations | GB | AVCODES |
| 4573 | EQ | Trans European Airways (UK) Ltd. d/b/a TEA (UK) Ltd. | ICAO: TUK, Callsign: Teastar, Ceased operations on 27 September 1991. | GB | AVCODES |
| 4574 | EQ | Fly AO-Linhas Aereas, Limiteda d/b/a Fly AO Angola | ICAO: FLA, | ANG | AVCODES |
| 4575 | EQA | Eagle Aviation Ltd. | IATA: Y4, Callsign: Magnum, IATA Prefix: 067, Ceased operations. | EAK | AVCODES |
| 4576 | EQAA | ELMINI LIZARD, INC. | | | SCAC3 |
| 4577 | EQAB | ELMINI LOAD, INC. | | | SCAC3 |
| 4578 | EQAB | EQUIPMENTS LOURDS PAPINEAU INC | | | SCAC4 |
| 4579 | EQAC | ELMINI LOGIC, INC. | | | SCAC3 |
| 4580 | EQAD | ELMINI LOOM, INC. | | | SCAC3 |
| 4581 | EQAD | EQUIPE SERVICE ENR | | | SCAC4 |
| 4582 | EQAE | ELMINI LORY, INC. | | | SCAC3 |
| 4583 | EQAF | ELMINI LOT INC. | | | SCAC3 |
| 4584 | EQAF | EQ TRANSPORTATION INC | | | SCAC4 |
| 4585 | EQAG | E N E AEGIALI LTD | | | SCAC3 |
| 4586 | EQAH | ELMINI LUNAR, INC. | | | SCAC3 |
| 4587 | EQAI | ELMINI LYMPH, INC. | | | SCAC3 |
| 4588 | EQAI | EQUIPMENT ASSOCIATES INC | | | SCAC4 |
| 4589 | EQAJ | ELMINI LEG, INC. | | | SCAC3 |
| 4590 | EQAS | EAS LINE | | | SCAC3 |
| 4591 | EQBC | EQUITABLE BAG CO INC | | | SCAC3 |
| 4592 | EQC | Ecuatorial Cargo | Callsign: Ecua-Cargo, | GQ | AVCODES |
| 4593 | EQC | Ecuatorial Cargo | | | ICAO1 |
| 4594 | EQCE | E N E CRETE | | | SCAC3 |
| 4595 | EQCI | EQUITY CARRIERS 111, INC | | | SCAC3 |
| 4596 | EQCO | EQUITY CARRIERS 1, INC | | | SCAC3 |
| 4597 | EQCX | Equa-Chlor LLC | added 7/2006; eliminated 7/2008 | | NAKINA |
| 4598 | EQCX | EQUA-CHLOR LLC | | | PWRC |
| 4599 | EQCX | EQUA-CHLOR LLC | | | SCAC4 |
| 4600 | EQDA | ELCAPITAIN, INC. | | | SCAC3 |
