| 201 | ZE | Arcus Air Logistic GmbH | ICAO: AZE, Callsign: Arcus Air, Name changed from Cosmos Air Luftfahrtunternehmen GmbH | D | AVCODES |
| 202 | ZE | Eastar Jet Co. Ltd. | ICAO: ESR, Callsign: Eastarjet, | ROK | AVCODES |
| 203 | ZEC | Zespół Elektrociepłowni Bydgoszcz S.A. | | PL | VKM |
| 204 | ZECN | ZEN CONTINENTAL CO., INC. | | | SCAC4 |
| 205 | ZECS | ZDS EXPRESS COURIERS | | | SCAC4 |
| 206 | ZEEL | ZEELAND FARM SERVICES INC | | | SCAC4 |
| 207 | ZEEN | ZEENA TRANSPORT INC | | | SCAC4 |
| 208 | ZEEU | ZEENNI S TRADING AGENCY | | RL | BIC |
| 209 | ZEFB | ZERO EIGHT FOUR FOUR ZERO FIVE FOUR | | | SCAC4 |
| 210 | ZEFL | ZENITH FREIGHT LINES LLC | | | SCAC4 |
| 211 | ZEKE | ZEKE UNLIMITED INC | | | SCAC4 |
| 212 | ZEKY | ZIP EXPRESS | | | SCAC4 |
| 213 | ZELI | ZEAL EXPRESS LOGISTICS INC | | | SCAC4 |
| 214 | ZELL | ZELLER, W TRANSPORTATION LTD | | | SCAC4 |
| 215 | ZELM | ZELLMER TRUCK LINES, INC | | | SCAC1 |
| 216 | ZELM | ZELLMER TRUCK LINES | | | SCAC4 |
| 217 | ZELPO | Železiarne Podbrezová a.s. | | SK | VKM |
| 218 | ZELPR | Železničná preprava, a.s. | | SK | VKM |
| 219 | ZELR | ZELLER TRANSPORTATION LLC | | | SCAC4 |
| 220 | ZELSD | Železara Smederevo d.o.o. | | RS | VKM |
| 221 | ZENC | ZEN CONTINENTAL CO INC | | | SCAC4 |
| 222 | ZENT | ZENITH TRANSPORT (1982) INC | | | SCAC4 |
| 223 | ZENTAN | Zentan Bus | | J | TRAFFIC |
| 224 | ZENU | ZEN BOX CO.,LTD | | USA | BIC |
| 225 | ZENU | ZENDE CONTAINER LEASING LIMITED | | | SCAC4 |
| 226 | ZEPHI | ZEPHIR S.p.A. | | IT | VKM |
| 227 | ZEPN | ZEPPELIN EXPRESS TRUCKING | | | SCAC4 |
| 228 | ZEPQ | ZEP TRANSPORTS INC | | | SCAC4 |
| 229 | ZERB | ZERBE BROTHERS INC | | | SCAC4 |
| 230 | ZERE | Zeretzke-Reisen | City: Dortmund | D | TRAFFIC |
| 231 | ZET | Zircon Express Togo | | TG | AVCODES |
| 232 | ZET | Zagreb Electric Tram | City: Zagreb | HR | TRAFFIC |
| 233 | ZETA | ZETA SYSTEM SRL | | | SCAC4 |
| 234 | ZETI | ZE TRANS INC | | | SCAC4 |
| 235 | ZETM | Z EXPRESS TRUCKING INC | | | SCAC4 |
| 236 | ZETT | ZERO EIGHT TWO ZERO TWO SEVEN SIX ( | | | SCAC4 |
| 237 | ZETU | ZETA SYSTEM SPA | | I | BIC |
| 238 | ZEUR | ZEUS TRANSPORT LLC | | | SCAC4 |
| 239 | ZEUS | ZEUS NAVIGATION COMPANY LIMITED | | | SCAC4 |
| 240 | ZEXI | ZAPIT EXPRESS INC | | | SCAC4 |
| 241 | ZEXL | ZOOM EXPRESS LLC | | | SCAC4 |
| 242 | ZEZF | ZERO EIGHT ZERO FIVE ONE TWO THREE | | | SCAC4 |
| 243 | ZF | Katekavia-limited company | ICAO: KTK, Callsign: Katekavia, Founded in May 1995. Name changed to Azur Air | RUS | AVCODES |
| 244 | ZF | Atlantic Airlines de Honduras, S de R.L. | ICAO: HHA, Callsign: Atlantic Honduras, Founded in 1991 by Atlantic Airlines of Nicaragua. Ceased Operations in October 2008. Company dissolved in 2009. | HN | AVCODES |
| 245 | ZF | Airborne of Sweden AB | ICAO: MIW, Callsign: Midwing, Designator ZF recalled by IATA | S | AVCODES |
| 246 | ZF | Athens Airways S.A. | ICAO: ATW, Callsign: Athens Airways, Founded in 2008. Commenced operations on 31 January 2009. Ceased operations in September 2010. | GR | AVCODES |
| 247 | ZF | Safari Express Cargo Limited | ICAO: SXY, Callsign: Safari Express, IATA Prefix: 925, | EAK | AVCODES |
| 248 | ZF | AZUR air Limited Liability Company | ICAO: KTK, Callsign: Azur Air, Founded in May 1995 as Katekavia. ICAO designator changed to AZV w.e.f. 29 March 2020. Name changed from Katekavia-limited company | RUS | AVCODES |
| 249 | ZF | AZUR air Limited Liability Company | ICAO: AZV, Callsign: Azur Air, Founded in May 1995 as Katekavia. ICAO designator changed from KTK w.e.f. 29 March 2020. Name changed from Katekavia-limited company | RUS | AVCODES |
| 250 | ZFA | SUIKER UNIE GMBH Zuckerfabrik Anklam | | DE | VKM |
| 251 | ZFAF | ZEHNER FARMS | | | SCAC4 |
| 252 | ZFBH | Željeznice Federacije Bosne i Hercegovine | | BA | VKM |
| 253 | ZFCM | ZIRKLE FRUIT COMPANY | | | SCAC4 |
| 254 | ZFEL | ZIEGLER, F ENTERPRISES LTD | | | SCAC4 |
| 255 | ZFKA | ZENTGRAF, FRITZ K | | | SCAC4 |
| 256 | ZFOD | ZARDA FOODS | | | SCAC4 |
| 257 | ZFP | Flight Plan Processing Center of ATMB, CAAC. | | PRC | AVCODES |
| 258 | ZFRG | ZANE FREIGHT | | | SCAC4 |
| 259 | ZFRN | ZIFFRIN TRUCK LINES INC | | | PWRC |
| 260 | ZFRT | Z FREIGHT | | | SCAC4 |
| 261 | ZFSX | ZEELAND FARM SERVICES, INC. | | | PWRC |
| 262 | ZFSX | ZEELAND FARM SERVICES INC | | | SCAC4 |
| 263 | ZFSY | ZEPHYR FREIGHT SYSTEMS | | | SCAC4 |
| 264 | ZG | Air Express Limited | ICAO: AEJ, Callsign: Khaki Express, | EAT | AVCODES |
| 265 | ZG | Viva Macau Limited | ICAO: VVM, Callsign: Jackpot, IATA Prefix: 887, Air Operator Certificate was revoked end March 2010. Designator ZG reinstated by IATA | MAC | AVCODES |
| 266 | ZG | Joint Stock Company Airline "Groznyy Avia" | ICAO: GOZ, Callsign: Groznyy Avia, AOC restricted by Authorities January 2017. | RUS | AVCODES |
| 267 | ZG | Zipair Tokyo, Inc. | ICAO: TZP, Callsign: Zippy, LCC subsidary of Japan Airlines. Established on 08 March 2019. Due to commence operations in Summer 2020 with 787-8 aircraft. | J | AVCODES |
| 268 | ZGBS | ZELLAR TRUCKING INC | | | SCAC4 |
| 269 | ZGHB | Zakłady Górniczo-Hutnicze “Bolesław” S.A. | | PL | VKM |
| 270 | ZGHL | Z & G HAULING LLC | | | SCAC4 |
| 271 | ZGHU | SHANGHAI ZHONGGU LOGISTICS CO., LTD. | | PRC | BIC |
| 272 | ZGIC | ZYGO GROUP INC | | | SCAC4 |
| 273 | ZGKC | Zakład Gospodarki Komunalnej w Cieszynie | City: Cieszyn | PL | TRAFFIC |
| 274 | ZGKY | ZAVALA GONZALEZ, KAREN YVETTE | | | SCAC4 |
| 275 | ZGLO | ZUNG TRANSPORT SOLUTIONS INC | | | SCAC4 |
| 276 | ZGLR | ZUNIGA VILLASANA, ISIDRO | | | SCAC4 |
| 277 | ZGLU | SHANGHAI ZHONGGU LOGISTICS CO., LTD. | | PRC | BIC |
| 278 | ZGMH | ZEIGLER, M H & SONS LLC | | | SCAC4 |
| 279 | ZGPKS | Zwiazek Gmin "Podkarpacka Komunikacja Samochodowa" | | PL | TRAFFIC |
| 280 | ZGRA | ZAPATA GUEVARA, ALDO A | | | SCAC4 |
| 281 | ZGRL | ZEIGLER, R L CO INC | | | SCAC4 |
| 282 | ZGRU | ZGROUP SAC | | PE | BIC |
| 283 | ZGXU | SHANGHAI ZHONGGU LOGISTICS CO., LTD. | | PRC | BIC |
| 284 | ZH | Air Truck Lineas Aereas, SA | ICAO: TRK, Callsign: Air Truck, Designator ZH recalled by IATA | E | AVCODES |
| 285 | ZH | Shenzhen Airlines | ICAO: CSZ, Callsign: Shenzhen Air, IATA Prefix: 479, IATA designator to changed from 4G w.e.f. 04 March 2002. Designator 4G reinstated by IATA | PRC | AVCODES |
| 286 | ZHESM | | | NL | TRAFFIC |
| 287 | ZHFU | ZHONG HAN YANTAI FERRY CO LTD | | PRC | BIC |
| 288 | ZHFU | YANTZI ZHONG HAN FERRY CO LTD | | | SCAC4 |
| 289 | ZHHU | XI'AN ZHONGHUI LIANHUA INDUSTRY CO., LTD | | PRC | BIC |
| 290 | ZHL | Freunde der Zahnradbahn Honau-Lichtenstein e.V. | Reutlingen | D | privat-bahn.de |
| 291 | ZHL | Freunde der Zahnradbahn Honau- Lichtenstein e.V | | DE | VKM |
| 292 | ZHLU | ZHENGHE LOGISTICS PTE LTD | | SGP | BIC |
| 293 | ZHROR | ZAHARUL ORADEA SA | | RO | VKM |
| 294 | ZHRT | ZEHR TRANSPORT LTD | | | SCAC4 |
| 295 | ZHRU | F.U.H TRANS-STAR S.C ZBIGNIEW, HALINA ROKOSZ | | PL | BIC |
| 296 | ZHWU | ZHAOHUA SUPPLY CHAIN MANAGEMENT GROUP CO., LTD. | | PRC | BIC |
| 297 | ZI | Aigle Azur | ICAO: AAF, Callsign: Aigle Azur, Ceased operations on 07 September 2019. IATA designator ZI reinstated by IATA. IATA designator ZI recalled by IATA | F | AVCODES |
| 298 | ZIBE | ZIBERT TRANSPORT CO | | | SCAC1 |
| 299 | ZIBU | ZHEJIANG LIANYUN BOX LOGISTICS TECHNOLOGY CO., LTD. | | PRC | BIC |
| 300 | ZICG | ŽELJEZNIČKA INFRASTRUKTURA CRNE GORE | | ME | VKM |
