| 1 | E | Evangeline Ry. | 1/1950-1/1952 | | NAKINA |
| 2 | E | Evangeline Ry. | Jan-52 | | NRHS |
| 3 | E | EVANGELINE RWY. | | | PWRC |
| 4 | E | Essener Verkehrs AG | Real: EVAG, City: Essen | D | TRAFFIC |
| 5 | E&E | Elberton & Eastern R.R. Co. | 7/1923-7/1932 | | NAKINA |
| 6 | E&E | ELBERTON & EASTERN RAILROAD CO. | | | PWRC |
| 7 | E&I | Evansville & Indianapolis R.R. (Evansville, Indianapolis & Terre Haute Ry.) | 8/1920-7/1923 | | NAKINA |
| 8 | E&I | EVANSVILLE, INDIANAPOLIS & TERRE HAUTE RWY. [EVANSVILLE & INDIANAPOLIS RAILROAD] | | | PWRC |
| 9 | E&M | Erie & Michigan Ry. & Navigation Co. | 8/1920-4/1938 | | NAKINA |
| 10 | E&M | Erie & Michigan Ry. & Navigation Co. | Apr-38 | | NRHS |
| 11 | E&M | *ERIE & MICHIGAN RWY. & NAVIGATION CO. | | | PWRC |
| 12 | E&M | *ETNA & MONTROSE RR | | | PWRC |
| 13 | E&VR | EMPORIUM & RICH VALLEY RR | | | PWRC |
| 14 | E&WC | East and West Coast Ry. | 7/1923 | | NAKINA |
| 15 | E&WC | EAST & WEST COAST RAILWAY | | | PWRC |
| 16 | E0 | Eos Airlines Inc. | ICAO: ESS, Callsign: New Dawn, IATA Prefix: 646, Ceased Operations on 30 April 2008. | USA | AVCODES |
| 17 | E1 | E-Savtravel | Computer Reservations Systems (CRS) | PE | AVCODES |
| 18 | E2 | Edelweiss Holdings, Inc. d/b/a Rio Grande Air | ICAO: GRN, Callsign: Grande, IATA designator changed from 1I | USA | AVCODES |
| 19 | E2 | Kampuchea Airlines | ICAO: KMP, Callsign: Kampuchea, IATA Prefix: 837, Ceased operations 2004. Designator KT recalled by IATA | K | AVCODES |
| 20 | E2 | Eagle Atlantic Airlines Limited | ICAO: EAB, | GH | AVCODES |
| 21 | E2 | Eurowings Europe GmbH | ICAO: EWE, Subsidary of Eurowings Germany. | A | AVCODES |
| 22 | E3 | Domodedovo Airlines Joint Stock Aircompany | ICAO: DMO, Callsign: Domodedovo, IATA Prefix: 497, Name changed from Joint Stock Aircompany Domodedovo Airlines | RUS | AVCODES |
| 23 | E3 | Joint Stock Aircompany Domodedovo Airlines | ICAO: DMO, Callsign: Domodedovo, IATA Prefix: 497, Name changed to Domodedovo Airlines Joint Stock Aircompany | RUS | AVCODES |
| 24 | E3 | Air Evasion | | F | AVCODES |
| 25 | E3 | Eagles S.p.A. | ICAO: EGS, Ceased operations. IATA desinator changed from GL* | I | AVCODES |
| 26 | E3 | Sabaidee Airways Co., Ltd. t/a New Gen Airways | ICAO: VGO, Callsign: Virgo, Name changed to NewGen Airways Compnay Limited t/a NewGen Airways. | T | AVCODES |
| 27 | E3 | NewGen Airways Compnay Limited t/a NewGen Airways | ICAO: VGO, Callsign: Virgo, Name changed from Sabaidee Airways Co., Ltd. t/a New Gen Airways. | T | AVCODES |
| 28 | E3 | EGO Airways S.p.A. | ICAO: EGW, Callsign: Egol, Founded on 29 July 2019. AOC received on 19 November 2020. Licence revoked by ENAC w.e.f. 04/01/2022. | I | AVCODES |
| 29 | E4 | Aero Asia International (Private) Ltd. | ICAO: RSO, Callsign: Aero Asia, IATA Prefix: 532, | PK | AVCODES |
| 30 | E4 | Eastok Avia | ICAO: EAA, Callsign: Eastok, Name changed to Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company | KS | AVCODES |
| 31 | E4 | Enter Air Sp. z.o.o. | ICAO: ENT, Callsign: Enter, | PL | AVCODES |
| 32 | E4 | Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company | ICAO: EAA, Callsign: Eastok, Name changed to Air Bishkek. Name changed from Eastok Avia. | KS | AVCODES |
| 33 | E4 | Air Bishkek | ICAO: EAA, Callsign: Eastok, Name changed from Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company. Name changed from Eastok Avia. | KS | AVCODES |
| 34 | E4 | Estelar Latinoamerica C.A. | ICAO: ETR, Callsign: Estel, | YV | AVCODES |
| 35 | E5 | Samara Airlines | ICAO: BRZ, Callsign: Beryoza, IATA Prefix: 906, | RUS | AVCODES |
| 36 | E5 | Air Arabia Egypt | ICAO: RBG, Callsign: Arabia Egypt, IATA Prefix: 844, | ET | AVCODES |
| 37 | E6 | AviaExpressCruise Airlines | ICAO: AEQ, Designator E6 reinstated by IATA | RUS | AVCODES |
| 38 | E6 | Bringer Air Cargo Taxi Aereo Ltda | ICAO: BRC, IATA Prefix: 417, ICAO designator changed to BCT. | BR | AVCODES |
| 39 | E6 | Bringer Air Cargo Taxi Aereo Ltda. | ICAO: BCT, IATA Prefix: 417, ICAO changed from BRC. | BR | AVCODES |
| 40 | E7 | European Aviation Air Charter Limited d/b/a European Air Charter | ICAO: EAF, Callsign: Eurocharter, Designator E7 reinstated by IATA. Ceased operations | GB | AVCODES |
| 41 | E7 | Estafeta Carga Aerea, S.A. de C.V. | ICAO: ESF, IATA Prefix: 355, | MEX | AVCODES |
| 42 | E7 | Fly European Airlines | ICAO: FLE, Callsign: Eurobuzz, Desinator E7* recalled by IATA | S | AVCODES |
| 43 | E7 | Downeast Flying Services, Inc. d/b/a Downeast Express | ICAO: DOW, Name changed to Downeast Flying Service, Inc. d/b/a Northeast Airlines. IATA designator changed to NE | USA | AVCODES |
| 44 | E7 | Equaflight Service | ICAO: EKA, Callsign: Equaflight, | RCB | AVCODES |
| 45 | E8 | ALPI Eagles S.p.A. | ICAO: ELG, Callsign: Alpi Eagles, AOC suspended bu Authorties during October 2007. | I | AVCODES |
| 46 | E8 | JSC Semeyavia | ICAO: SMK, Callsign: Ertis, | KZ | AVCODES |
| 47 | E8 | City Airways Company Limited dba City Airways | ICAO: GTA, Callsign: City Airways, Commenced operations in September 2012. Suspended operations on 13 February 2016. | T | AVCODES |
| 48 | E8 | Tayaran Jet JSC | ICAO: TJB, Callsign: Aladin, Designator E8 recalled by IATA. | BG | AVCODES |
| 49 | E9 | Compagnie Africaine d'Aviation CAA | | ZRE | AVCODES |
| 50 | E9 | AJT Air International | ICAO: TRJ, Callsign: Turjet, IATA Prefix: 766, IATA designator Re-Assigned | RUS | AVCODES |
| 51 | E9 | Boston-Maine Airways Corp. d/b/a Pan Am Clipper Connection | ICAO: CXS, Callsign: Clipper Express, Founded in 1999. Ceased operations in 2008. ICAO Designator and Callsign changed to PXS / Panam Express | USA | AVCODES |
| 52 | E9 | Aircuenca S.A. | | EC | AVCODES |
| 53 | E9 | Compagnie Africaine d'Aviation CAA | IATA Designator changed to BU | ZRE | AVCODES |
| 54 | E9 | Evelop Airlines S.L. | ICAO: EVE, Callsign: Evelop, IATA Prefix: 783, Name changed to Evelop Airlines S.L. d/b/a iberojet | E | AVCODES |
| 55 | E9 | Evelop Airlines S.L. d/b/a iberojet | ICAO: EVE, Callsign: Evelop, IATA Prefix: 783, Name changed from Evelop Airlines S.L. | E | AVCODES |
| 56 | EA | European Air Express | ICAO: EAE, Callsign: Noris, ICAO callsdin changed to Starwing. IATA designator changed from 7Y*. ICAO changed from NRX, Formely Filder Air Servic Airlines | D | AVCODES |
| 57 | EA | European Regions Airlines | ICAO: EEE, Declared bankrupt on 10 October 2000. | E | AVCODES |
| 58 | EA | Eastern Air Lines | ICAO: EAL, Callsign: Eastern, Ceased operations on 18 January 1991. | USA | AVCODES |
| 59 | EA | ERA European Regions Airlines | ICAO: EUA, Callsign: Golden Angel, Ceased operations on 13 October 2000 | E | AVCODES |
| 60 | EA | European Air Express | ICAO: EAE, Callsign: Starwing, ICAO callsdin changed from Noris. IATA designator changed from 7Y*. ICAO changed from NRX, Formely Filder Air Servic Airlines | D | AVCODES |
| 61 | EA | Andalus Lines Aereas | ICAO: ANU, Callsign: Andalus, IATA Prefix: 480, Founded in 2008. Commenced operations on 27 February 2009. Ceased operations on 13 August 2010. | E | AVCODES |
| 62 | EA | Eastern Skyjets | ICAO: ESJ, Callsign: Eastern Skyjets, IATA Designator changed to EE. | UAE | AVCODES |
| 63 | EA | East Horizon Airlines | ICAO: EHN, Callsign: East Horizon, | AFG | AVCODES |
| 64 | EA | Eastern Air Lines Group, Inc. | ICAO: EAL, Callsign: Eastern, Merged into Swift Air w.e.f. September 2017. IATA designator changed from EE | USA | AVCODES |
| 65 | EA | Atlantis-Air Link Ltd. | IATA Prefix: 827, | CDN | AVCODES |
| 66 | EA | Emerald Airlines (Ireland) Limited | ICAO: EAI, Callsign: Gemstone, | IRL | AVCODES |
| 67 | EAA | Transporte Aereo Andino, S.A. (TAAN) | Callsign: Tandino, | YV | AVCODES |
| 68 | EAA | Eastok Avia | IATA: E4, Callsign: Eastok, Name changed to Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company | KS | AVCODES |
| 69 | EAA | Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company | IATA: E4, Callsign: Eastok, Name changed to Air Bishkek. Name changed from Eastok Avia. | KS | AVCODES |
| 70 | EAA | Air Bishkek | IATA: E4, Callsign: Eastok, Name changed from Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company. Name changed from Eastok Avia. | KS | AVCODES |
| 71 | EAA | Air Bishkek Aircompany d/b/a Air Bishkek Ltd. | IATA: KR, Callsign: Eastok, IATA Prefix: 265, Ceased operations in February 2016. Name changed from Kyrgyz Airways d/b/a Kyrgyz Airways Ltd. Air Company. Name changed from Eastok Avia. | KS | AVCODES |
| 72 | EAAA | EQUIPO AUTOMOTRIZ AMERICANA SA DE C | | | SCAC4 |
| 73 | EAAG | EASTERN AGENTS | | | SCAC3 |
| 74 | EAAG | EASY MOTION HORSE PRODUCTS INC | | | SCAC4 |
| 75 | EAAT | EASTERN AGRICULTURE TRANSPORT | | | SCAC3 |
| 76 | EAAV | EAGLE OF THE DAWN ARTIST LTD | | | SCAC4 |
| 77 | EAAZ | EAST ALCOA ALUMINUM COMPANY | | | PWRC |
| 78 | EAB | Eagle Air Ltd. | Callsign: Swiss Eagle, Name changed to Swiss Eagle AG | CH | AVCODES |
| 79 | EAB | Swiss Eagle AG | Callsign: Swiss Eagle, Name changed from Eagle Air Ltd. | CH | AVCODES |
| 80 | EAB | Eagle Atlantic Airlines Limited | IATA: E2, | GH | AVCODES |
| 81 | EAB | Eagle Atlantic Airlines Limited | Designator E2 recalled by IATA | GH | AVCODES |
| 82 | EAB | Swiss Eagle | | | ICAO1 |
| 83 | EABC | EDELEN & BOYER CO | | | SCAC3 |
| 84 | EABI | EASTLICK, BILL TRUCKING | | | SCAC3 |
| 85 | EABI | EASTLICK TRUCKING | | | SCAC4 |
| 86 | EABT | EARLY BIRD TRUCKING CORP | | | SCAC3 |
| 87 | EAC | Executive Air Charter | Callsign: Execair, | USA | AVCODES |
| 88 | EAC | Executive Air Charter | | | ICAO1 |
| 89 | EAC | EXPRESSWA | | | SCAC4 |
| 90 | EACD | EACRETT, DOUGLAS | | | SCAC3 |
| 91 | EACE | EASTERN CARRIERS INC | | | SCAC3 |
| 92 | EACG | EAST CENTRAL TRUCKING LLC | | | SCAC4 |
| 93 | EACH | East Camden & Highland R.R. Co. | 1/1975-7/2005 | | NAKINA |
| 94 | EACH | East Camden & Highland R.R. Co. | 1/75-7/2000 | | NRHS |
| 95 | EACH | EAST CAMDEN & HIGHLAND RR CO. | | | PWRC |
| 96 | EACH | East Camden and Highland Railroad | | | RSRV |
| 97 | EACH | EAST CAMDEN & HIGHLAND RR CO | | | SCAC3 |
| 98 | EACH | EAST CAMDEN & HIGHLAND RR CO | | | SCAC4 |
| 99 | EACH | East Camden and Highland Railroad | | USA | TRAFFIC |
| 100 | EACJ | EASTERN CONSOLIDATED | | | SCAC3 |
