| 1 | S5 | Shuttle America | ICAO: TCF, Callsign: Shuttlecraft, Name changed to Shuttle America Corporation. ICAO callsign changed to Mercury. Designator S5 reinstated by IATA. Operates as US Airways Express | USA | AVCODES |
| 2 | S5 | Saeaga Airlines | ICAO: SGG, Callsign: Saeaga, Designator S5 recalled by IATA | MAL | AVCODES |
| 3 | S5 | Trast Aero | ICAO: TSJ, | KS | AVCODES |
| 4 | S5 | Shuttle America Corporation | ICAO: TCF, Callsign: Mercury, Merged into Republic Airline on 31 January 2017. Name changed from Shuttle America. ICAO callsign changed from Shuttlecraft. Designator S5 reinstated by IATA. Operates as US Airways Express | USA | AVCODES |
| 5 | S5 | Small Planet Airlines UAB | ICAO: LLC, Callsign: Small Planet, Ceased operations on 28 November 2018. | LT | AVCODES |
| 6 | S5 | Abakan Air LLC | ICAO: NKP, Callsign: Abakan Air, IATA Prefix: 917, | RUS | AVCODES |
| 7 | S5 | Ghodawat Enterprises Pvt. Ltd. d/b/a Ghodawat Aviation | ICAO: SDG, Callsign: Hi Star, Name changed to Ghodawat Enterprises Pvt. Ltd. d/b/a Star Air. IATA designator changed from OG*. | IND | AVCODES |
| 8 | S5 | Ghodawat Enterprises Pvt. Ltd. d/b/a Star Air | ICAO: SDG, Callsign: Hi Star, Name changed from Ghodawat Enterprises Pvt. Ltd. d/b/a Ghodawat Aviation. IATA designator changed from OG*. | IND | AVCODES |
